DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways
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منابع مشابه
DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways
DBF4-dependent kinase (DDK) is a two-subunit kinase required for initiating DNA replication at individual origins and is composed of CDC7 kinase and its regulatory subunit DBF4. Both subunits are highly expressed in many diverse tumor cell lines and primary tumors, and this is correlated with poor prognosis. Inhibiting DDK causes apoptosis of tumor cells, but not normal cells, through a largely...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2017
ISSN: 1476-5586
DOI: 10.1016/j.neo.2017.03.001